The Mariana backarc, the same location of the deepest point on Earth, is where the thermal vents occur due to the spreading of two plates. In other words, the spreading apart of the sea floor results in a trench like the Mariana trench. At such backarcs, and the similar but not the same Mid-Ocean Ridges, “black smokers” form.
The following video is a fly-thru movie at the Mariana backarc in search for HydroThermal vents (second video).
The video below by researchers at the Harvard Medical School and Technion–Israel Institute of Technology shows bacteria break zones of ever increasing concentrations of antibiotics hence demonstrates how bacteria becomes “impervious to drugs”. They are able to
In a creative stroke inspired by Hollywood wizardry, scientists from Harvard Medical School and Technion-Israel Institute of Technology have designed a simple way to observe how bacteria move as they become impervious to drugs. 
Cerebrospinal fluid (CSF) acts as a detoxing agent removing toxins built up while the brain is conscious.
CSF influx only happens during sleep. It is inhibited during wakefulness.
and we discovered that at the same timewhen the brain goes to sleep,the brain cells themselves seem to shrink,opening up spaces in between them,allowing [cerebrospinal fluid – CSF] fluid to rush through and allowing waste to be cleared out.
But our most surprising findingwas that all of this,everything I just told you about,with all this fluid rushing through the brain,it’s only happening in the sleeping brain.
I found an interesting poster on brain connectivity associations of the ASR syndrome categorized by scales (depressed, stomach complaint, withdrawn, attention problems, thought problems, tobacco use, etc…) presented during the 2014 meeting of the Society of Biological Psychiatry (SOBP 2014) and wanted to share the graphic (2nd image) with you.